Publications

2024

Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams

Z. Yang, M. Arnoux, D. Hazelard, O. R. Hughes, J. Nabaroo, A. C. Whitwood, M. A. Fascione, C. D. Spicer, P. Compain, W. P. Unsworth; Org. Biomol. Chem., DOI:10.1039/D4OB00285G.

Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion

C. Jumeaux, C. D. Spicer, P. Charchar, P. D. Howes, M. N. Holme, L. Ma, N. C. Rose, J. Nabarro, M. A. Fascione, M. Harunur Rashid, I. Yarovsky, M. M. Stevens; Angew. Chem. Int. Ed., 2024, 136, e202314786.

Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs

C. Hagemann, M. C. D. Bailey, E. Carraro, K. S. Stankevich, V. M. Lionello, N. Khokhar, P. Suklai, C. Moreno-Gonzalez, K. O’Toole, G. Konstantinou, C. L. Dix, S. Joshi, E. Giagnorio, M. S. Bergholt, C. D. Spicer, A. Imbert, F. S. Tedesco, A. Serio; PLOS Biology, DOI:10.1371/journal.pbio.3002503.

Crossing the solubility Rubicon: 15-crown-5 facilitates the preparation of water-soluble sulfo-NHS esters in organic solvents

N. D. J. Yates, C. G. Miles, C. D. Spicer, M. A. Fascione, A. Parkin; Bioconj. Chem., 2024, 35, 22-27.

2023

Hydrogel cross-linking via thiol-reactive pyridazinediones

C. Bahou, R. J. Spears, A. M. Ramírez Rosales, L. N. C. Rochet, L. J. Barber, K. S. Stankevich, J. F. Miranda, T. C. Butcher, A. M. Kerrigan, V. K. Lazarov, W. Grey, V. Chudasama, and C. D. Spicer; Biomacromolecules, 2023, 24, 4646-4652.

Preparation and application of an inexpensive α-formylglycine building block compatible with Fmoc solid-phase peptide synthesis

N. D. Yates, M. E. Warnes, R. Breetveld, C. D. Spicer, N. Y. M. Signoret, and M. A. Fascione; Org. Lett., 2023, 25, 2001-2005.

Selectivity and stability of N-terminal targeting protein modification chemistries

L. J. Barber, N. D. Yates, M. A. Fascione, A. Parkin, G. R. Hemsworth, P. G. Genever, and C. D. Spicer*; RSC Chem. Bio, 2023, 4, 56-64.

2022

Insight into ortho-boronoaldehyde conjugation via a FRET-based reporter assay

N. C. Rose, A. V. Sanchez, E. F. Tipple, J. M. Lynam, and C. D. Spicer*; Chem. Sci., 2022, 13, 12791-12798.

Nuclear magnetic resonance and metadynamics simulations reveal the atomistic binding of l-serine and O-phospho-l-serine at disordered calcium phosphate surfaces of biocements

R. Mathew, B. Stevensson, M. Pujari-Palmer, C. S. Wood, P. R. A. Chivers, C. D. Spicer, H. Autefage, M. M. Stevens, H. Engqvist, and M. Edén; Chem. Mater., 2022, 34, 8815-8830.

2021

High throughput peptide derivatization towards (supra)molecular diversification in microtiter plates

Y. Lin, M. Penna, C. D. Spicer, S. G. Higgins, A. Gelmi, N. Kim, S. T. Wang, J. P. Wojciechowski, E. T. Pashuck, I. Yarovsky, and M. M. Stevens; ACS Nano, 2021, 15, 4034-4044.

Photochemical methods for peptide macrocyclization

L. Raynal, N. C. Rose, J. R. Donald, and C. D. Spicer*; Chem. Eur. J., 2021, 27, 69-88.

2020

Tuneable peptide cross-linked nanogels for enzyme triggered protein delivery

L. Massi, A. Najer, R. Chapman, C. D. Spicer, V. Nele, M. A. Booth, J. J. Doutch, and M. M. Stevens; J. Mater. Chem. B, 2020, 8, 8894-8907.

An electroactive oligo‐EDOT platform for neural tissue engineering

K. I. Ritzau-Reid‡, C. D. Spicer‡, A. Gelmi, C. L. Grigsby, J. F. Ponder, V. Bemmer, R. Vilar, A. Serio, and M. M. Stevens; Adv. Func. Mater., 2020, 30, 2003710.

Synthesis of phospho-amino acid analogues as tissue adhesive cement additives

C. D. Spicer*, M. Pujari-Palmer, H. Autefage, G. Insley, P. Procter, H. Engqvist, and M. M. Stevens; ACS Cent. Sci., 2020, 6, 226-231.

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

C. D. Spicer*; Polym. Chem., 2020, 11, 184-219.

2015-2020

Shape-controlled synthesis and in situ characterisation of anisotropic Au nanomaterials using liquid cell transmission electron microscopy

S. T. Wang, Y. Lin, M. N. Nielsen, C. Yu Song, M. R. Thomas, C. D. Spicer, R. Kröger, P. Ercius, S. Aloni, and M. M. Stevens; Nanoscale, 2019, 11, 16801-16809.

A novel class of injectable bioceramics that glue tissues and biomaterials

M. Pujari-Palmer, H. Guo, D. Wenner, H. Autefage, C. D. Spicer, M. M. Stevens, O. Omar, P. Thomsen, M. Edén, G. Insley, P. Procter, and H. Engqvist; Materials, 2018, 11, 2492.

Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis

M. K. Bilyard, H. Bailey, L. Raich, M. Gafitescu, T. Machida, J. Iglesias-Fernández, S. S. Lee, C. D. Spicer, C. Rovira, W. W. Yue, and B. G. Davis; Nature, 2018, 563, 235-240.

Achieving controlled biomolecule-biomaterial conjugation

C. D. Spicer*, E. T. Pashuck, and M. M. Stevens*; Chem. Rev., 2018, 16, 7702-7743.

Duplex specific nuclease-amplified detection of MicroRNA using compact quantum dot-DNA conjugates

Y. Wang, P. D. Howes, E. Kim, C. D. Spicer, M. R. Thomas, Y. Lin, S. C. Crowder, I. J. Pence, and M. M. Stevens; ACS Appl. Mater. Interfaces, 2018, 10, 28290-28300.

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

C. D. Spicer*, C. Jumeaux, B. Gupta, and M. M. Stevens*; Chem. Soc. Rev., 2018, 47, 3574-3620.

Electrospun aniline-tetramer-co-polycaprolactone fibres for conductive, biodegradable scaffolds

A. G. Guex, C. D. Spicer, A. Armgarth, A. Gelmi, E. J. Humphrey, C. M. Terracciano, S. Harding, and M. M. Stevens; MRS Commun., 2017, 7, 375-382.

Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore

S. T. Wang, Y. Lin, C. C. Hsu, N. Amdursky, C. D. Spicer, and M. M. Stevens; Talanta, 2017, 173, 44-50.

Facet dependent islet amyloid polypeptide interactions with gold nanoparticles: Implications for fibril formation and peptide-induced lipid membrane disruption

S. T. Wang, Y. Lin, N. Todorova, Y. Xu, M. Mazo, S. Rana, V. Leonardo, N. Amdursky, C. D. Spicer, B. D. Alexander, A. A. Edwards, S. J. Matthews, I. Yarovsky, and M. M. Stevens; Chem. Mater., 2017, 29, 1550-1560.

Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels

P. A. Parmar, J. P. St-Pierre, L. W. Chow, C. D. Spicer, V. Stoichevska, Y. Y. Peng, J. A. Werkmeister, J. A. M. Ramshaw, and M. M. Stevens; Acta Biomater., 2017, 51, 75-88.

Synthesis of hetero-bifunctional, end-capped oligo-EDOTs for tissue engineering applications

C. D. Spicer, M. A. Booth, D. Mawad, A. Armgarth, C. B. Nielsen, and M. M. Stevens; Chem, 2017, 2, 125-138.

Selective etching of injection molded zirconia-toughened alumina: towards osseointegrated and antibacterial ceramic implants

Q. Flamant, C. Caravaca, S. Meille, L. Gremillard, J. Chevalier, K. Biotteau-Deheuvels, M. Kuntz, R. Chandrawati, I. K. Herrmann, C. D. Spicer, M. M. Stevens, and M. Anglada; Acta Biomater., 2016, 46, 308-322.

Bio-inspired Maillard-like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

S. T. Wang, Y. Lin, C. D. Spicer, and M. M. Stevens; Chem. Commun., 2015, 51, 11026-11029.

Designing logical codon reassignment – Expanding the chemistry in biology

A. Dumas‡, L. Lercher‡, C. D. Spicer‡, and B. G. Davis; Chem. Sci., 2015, 6, 50-69.